Rezende Laboratory
at Brigham and Women’s Hospital
THE GUT-BRAIN CONNECTION
We explore the gut-brain axis through the fusion of immunology, neuroscience, and microbiology.
How is behavior and brain cell populations effected in disease?
What role does the immune system in the development of animal behavior?
How do gut microbes interact with the immune system and brain to drive behavioral abnormalities?
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How is behavior and brain cell populations effected in disease?
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What role does the immune system in the development of animal behavior?
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How do gut microbes interact with the immune system and brain to drive behavioral abnormalities?
A shift in microbial populations in the gut has been associated with various neurological diseases and plays a role in the health of the mucosal immune system. By using next generation sequencing techniques, behavioral assays, and metabolomics we probe the complex relationships between the immune system and brain of the host and the gut microbiome to understand what it means to be healthy on a multi-organismal level. We hope these insights could pave the way for future novel therapeutics targeting involuted neurological disorders.